Sentence examples for variants that enhanced from inspiring English sources

Several palivizumab variants that enhanced the neutralization of RSV in vitro by up to 44-fold were generated; however, in vivo prophylaxis of cotton rats with these antibodies conferred only about a twofold improvement in potency over palivizumab.

To further highlight the importance of L29 in maintaining protein expression, we used mutagenesis and selection to obtain L29 variants that enhanced GFP expression.

For instance Wang et al, through the use of a multistep screening process, succeeded in isolating GroEL variants that enhanced the expression of GFP and circularly permuted versions of GFP 3-8-fold, presumably by enhancing folding of GFP in vivo.

An important goal of protein engineering is designing variants that enhance the conformational stability of proteins.

In the present study, we used directed evolution to identify specific amino acid mutations from a pool of randomly mutated variants that enhance the stability of the protein fold.

Variants that enhance a cell's evolutionary fitness, so-called driver mutations, promote outgrowth of that clone and progression toward cancer (Stratton et al., 2009).

Because loci linked to drive alleles also benefit from the transmission advantage, linked variants that enhance drive will also be selected (Crow, 1991).

Furthermore, we found that the gatekeeper variant, that enhances kinase activity, is not refractory to some of the inhibitors currently in clinical trials; in particular, TKI258 retained its efficacy towards FGFR1 and FGFR3 gatekeeper substitutions in vitro and in cells.

Since an appealing hypothesis would be that these peptides are generated by the virus to act as antimicrobial agents that favor viral infectivity in their fish host, we decided to test this possibility by selecting a master peptide and using it to generate substitution variants that may enhance their antimicrobial potential.

In germline DNA, all pathogenic BRCA1 and BRCA2 mutations will exist in heterozygous form giving rise to heteroduplexes that enhance variant detection by HRM.

This variant was engineered to combine mutations that enhance MBP solubility and affinity purification, as well as provide crystal-packing interactions for increased crystallizability.