Sentence examples for variants that drive from inspiring English sources

8 10 11 The possibility of rare genetic variants that drive a pronounced clinical phenotype was not explored in this study, because only variants with minor allele frequencies >0.05 were assessed.

Although the preferential localization downstream in these genes could represent a distinct regulatory signal targeting this gene set, a more plausible explanation is that the genes in question are overlapping other genes (or gene variants) that drive the association to H3K4me2 modifications.

Evidence also exists for the periodic emergence of new GII.4 strain variants that cause large global epidemics, possibly driven by escape from herd immunity (5, 10 ).

Because loci linked to drive alleles also benefit from the transmission advantage, linked variants that enhance drive will also be selected (Crow, 1991).

Cell lines offer increased sample sizes relative to traditional studies, resulting in higher statistical power to detect genetic variants that potentially drive drug response.

We reasoned that such persistent changes will include those variants that were driven to sufficiently high frequency by selection to ensure repeated sampling, whereas non-persistent (transient) ones do not.

Pogoplug has some open source variants that enable UPNP, but this drive does not support those updates – yet.

Many cancers, however, including high-grade serous ovarian, oesophageal, and small-cell lung cancer, are driven by somatic structural variants that are not measured by these assays.

The processes of molecular drive (see [ 48] for a review on molecular drive) affecting the pDo500 satDNA may also lead to an accumulation of variants that do not perfectly reflect the phylogenetic relationships.

PDE4 splice variant synthesis proceeds through alternative splicing via the incorporation of distinct promoters (alternative transcription start sites) that drive differential tissue expression and transcriptional regulation [ 11- 13].

Furthermore, the number of potential genetic variants that lead to disease susceptibility is ever-expanding, including novel SNPs or de novo copy number variants that will drive future mouse modelling experiments (127) as well as epigenetic and environmental factors.