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What can be done to minimize the health risk posed by viral variants that develop resistance and cause failure of therapy?
Long forms containing CC and PR domains induce thick, spindle-shaped bundles, whereas short isoforms lacking CC and PR induce more slender variants that develop into densely woven networks.
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The aetiology of breast cancer is complex but involves selection of variant cells that develop a growth advantage over and above that of the surrounding normal epithelium.
Recent studies have made progress in obtaining bright variants of these proteins that develop chromophores quickly and efficiently, as well as novel fluorescent proteins that photoconvert (i.e. change color upon illumination at specific wavelengths).
Yoga has boomed in the west in the past couple of decades, and many of the variants that have developed have moved away from its meditative origins.
Lead-time and lag-time TTO are relatively new variants that were developed to address problems with conventional TTO.
To that end, targeting of ovarian tumors by VSV was evaluated in an immune-competent Wv (white spotting variant) mouse model that develops ovarian epithelial tumors spontaneously [114]– [114].
For this experiment we chose the chronic relapsing variant of CIA that develops in mice with mixed B10 and BALB/c backgrounds.
Certain potentiated variants that we have developed suppress toxicity more strongly than others.
New techniques in the search for phenotype-associated genes (next-generation sequencing, genome-wide association studies) have expanded the spectrum of both monogenic PD and variants that alter risk to develop PD.
Directed evolution continues to expand the capabilities of complex biomolecules for a range of applications, such as adeno-associated virus vectors for gene therapy; however, advances in library design and selection strategies are key to develop variants that overcome barriers to clinical translation.
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