Sentence examples for variants that confer from inspiring English sources

These haplotypes in which SNPs are grouped in linkage disequilibrium blocks (tag SNP), identified by the HapMap project, can be used for the association study of genes as candidates for the presence of common variants that confer susceptibility to the disease.

Currently, genome-wide association studies (GWAS) are identifying common variants that confer low risk of complex disease.

Known HLA variants that confer risk to CD, for example, include DQA1*05/DQB1*02 (DQ2.5) and DQA1*03/DQB1*0302 (DQA1*03/DQB1*0302

If there are variants that confer protection as well as risk, both will tend to be included, but this is a fundamental problem of testing a collection of rare variants.

Thus, recently, the GWAS have identified multiple loci containing variants that confer risk of type 2 diabetes mellitus [ 1– 3].

There are several challenges for the application of GWAS to determine genetic variants that confer susceptibility to infectious diseases.

For variants that conferred a risk at p<0.05 for CHD, we also studied the association in prevalent CHD cases (documented or self-reported myocardial infarction or unstable angina pectoris at baseline), using healthy sub-cohort subjects as controls.

We hypothesized that there would be selection in favor of AHR variants that conferred reduced sensitivity to PCBs.

Some of the most important lung cancer drivers are mutations in the EGFR gene, for example, the exon 19 deletions and the L858R variant that confer sensitivity to the front line drugs erlotinib and gefitinib; the acquired T790M variants confer drug resistance and a poor prognosis.

This result revealed that the HMOX1c genetic variant that conferred increased risk to develop CM is also associated to higher expression of HMOX1 mRNA in the context of CM.

With several hundred cases and controls, very few genes have adequate power to identify a rare variant that confers an Odds ratio of 5 or more (Tennessen et al. 2012).