Sentence examples for variants that change from inspiring English sources
The deluge of data that are generated in WGES studies differ dramatically from DNA microarray-based GWAS since, theoretically, all the genetic variants that change protein sequences in an individual are catalogued, heightening the ethical and legal concerns encountered in traditional genetic studies.
We define variants that change coding sequences among species as critical variants.
This is often so for natural variants that change catalytic (or stability) properties of enzymes without altering their reaction mechanisms [ 42].
The transcript sequence and expression polymorphisms are also useful for eQTL (expression QTL) analysis to identify DNA variants that change expression levels and patterns of genes [ 68].
The distinction between the variants that change protein function and those that are neutral is one key to making sense of the deluge Next Generation Sequencing (NGS) or Deep Sequencing data.
For variants that fall within annotated gene structures, an understanding of the genetic code and splicing can be used to identify variants that change the coding sequence or disrupt the essential splice sites at either end of the intron.
Another position (10784) fell in the ND4 gene and was a nonsynonymous variant that changed the amino acid isoleucine to valine, but it appeared in a healthy individual belonging to haplogroup U6a1b (GenBank accession number: EF064320).
Nonsyn SNV, A single nucleotide variant that changes the amino acid produced by a codon.
Together, these findings argue for the presence of at least one cis-acting regulatory genetic variant that changes expression of SLC1A3 mRNA.
A missense variant is a sequence variant that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved (http://www.sequenceontology.org/miso/current_release/term/SO 0001583).org/miso/current_release/term/SO 0001583
Orp1-mediated oxidation, particularly by H2O2, induces a conformational change in the linked roGFP2 variant that changes its fluorescence from 488 to 405 nm excitation (Albrecht et al., 2011).
