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It is not possible to say which is most likely to be causative, as none of the candidate genes are known to harbor variants that cause the exact phenotype reported here.
Protein localization of variants that cause MYH3-related diseases.
"We think this will be the first of many common variants that cause obesity," said Alan Herbert, another leader.
So why have the genomewide association studies linked some SNPs to disease, if in fact it is the rare variants that cause it?
But why do the SNPs get implicated in the genomewide association studies if in fact it is the rare variants that cause disease?
Finding even a few of the rare variants that cause disease could point to genes that make suitable targets for drug makers.
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The theory behind the shortcut was that since the major diseases are common, so too would be the genetic variants that caused them.
These might eventually contribute to the identification of the selected variants that caused the signatures found.
The panel of strains included fHBP variants that represent approximately 70% of the variants that caused disease in these populations.
Subsequent researches using human genetics approaches identify loss-of-function GPR120 gene variants that caused increased incidence of obesity and related sequelae, especially in the context of high-fat diet [ 148].
Knome hasn't yet found any ticking time bombs, such as the genetic variant that causes Huntington's disease.
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