Sentence examples for variants that cannot from inspiring English sources

Thus in theory the genealogical, or stemmatic, method allows the critic to eliminate from consideration all variants that cannot be traced back to the archetype or earliest inferable textual state.

Family studies of exceptional longevity were performed also to identify rare genetic variants that cannot be discovered with population-based studies.

The advantage of KBAC is that the genotype patterns encompass a wide range of possible models of association; for example, allowing for interactions between rare variants that cannot be easily incorporated with simple linear functions, f.

Optical mapping data span much longer genomic ranges that commonly achievable mate-pair sizes, and thus have the ability to detect large-scale variants that cannot be detected using paired end reads.

Since the IRB consent does not allow communication of genetic data, given potential negative consequences of knowledge of variants that cannot be acted upon, the identities of the individuals are anonymous and no concerted attempt has been made here to link genotypes to phenotypes directly.

There are likely to be fundamental limits on precise individualized genetic risk prediction due to the complex architecture of common traits, including common variants of very small effect, rare variants that cannot be fully enumerated, and complex epistatic interactions, as well as stochastic and possible environmental factors.

Glukhova and colleagues used the CK5 promoter to overexpress a β-catenin variant, ΔN59Cat, that cannot be phosphorylated at a site necessary for normal turnover [ 17].

The optical mapping technique has been successfully used for assessing the quality of genome assemblies and for detecting large-scale structural variants and rearrangements that cannot be detected using current paired end sequencing protocols.

Our data show that in cells transfected with a plasmid encoding p66ShcS36A, variant that cannot be phosphorylated at serine 36, DATS-induced Akt dephosphorylation is suppressed.

Tethering PP1 directly to an Spc105 variant that cannot bind PP1 (Spc105RVSF-RASA) rescell celethalityity but, in contrast, tethering PP1 to wild-type Spc105 is lethal and cannot be rescued by disruption of the SAC (Rosenberg et al. 2011).

Moreover, a Ni-depleted recombinant enzyme and an active site variant that cannot complete the CO oxidation reaction (K563L) are devoid of activity and correspondingly do not exhibit significant CO broadening.