Sentence examples for variants that bind from inspiring English sources

Our findings support the hypothesis that the low breast cancer incidence observed in women with HIV/AIDS is specifically linked to HIV variants that bind to CXCR4, a receptor that is commonly expressed on hyperplastic and neoplastic breast cells.

Corresponding efforts have not only to avoid the use of antibody variants that bind Fc γRs but must also ensure lack of immunogenicity to prevent the development of cross-linking secondary antibodies.

We constructed a library of PDZ domains by randomizing residues in direct contact with position 0 and in a loop that is close to but does not contact position 0. We used phage display to select for PDZ variants that bind to 19 peptide ligands differing only at position 0. To verify that each obtained PDZ domain exhibited the correct binding specificity, we selected peptide ligands for each domain.

To further demonstrate the utility of our BiFC assay, we attempted to isolate gain-of-function DmsD variants that bind ssDmsA more efficiently.

This difference became most noticeable with the 4L and 5Y variants that bind with affinities of KD 117 μM and approximately 250 μM, respectively.

To select the clones expressing Cry8ka1 variants that bind specifically to the A. grandis midgut, the phage-display combinatorial library was used for biopanning.

Using G2 as a scaffold, we constructed phage-displayed libraries of FHA1 variants and affinity selected for variants that bound selectively to five pT peptides.

Screening one of the two mutagenic libraries yielded variants that bound two- to fourfold tighter to human Pak1 kinase than the starting clone.

To aid in this effort, we constructed and characterized two PHM variants that bound metal at only one site.

To tune the strength of the translational inhibition, we replaced the L7Ae protein, the K-turn RNA motif, or both with variants that bound with weaker affinity.

More recently we used a cloned 244/PR8 virus (Dimmock et al., 2008) reconstructed with a PR8 hemagglutinin variant that bound to both α 2,6- and α 2,3-linked sialyl receptors (Meng et al., 2010), so that DI RNA would be delivered to and protect cells bearing both types of receptor.