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Instead, McClellan and King think we ought to pay more attention to rare variants that arose in our genomes relatively recently.
We found that variants that arose during evolution occurred frequently among CID classes.
We then defined a second threshold, T 2, to eliminate artifactual variants that arose from substitution errors.
The few common SNPs that deviate from HWE could be relatively new variants that arose at a frequency similar to SNPs in other non-DNA-contacting regions of the protein.
Some of these ON1 viruses have partial G gene sequences identical to the few ON1 genotype GenBank sequences available from around the world, indicating that ON1 variants that arose soon after its emergence are also quickly spreading worldwide.
Considering the probability of substitution errors, the probability of artifactual variants (that arose from substitution errors) occurring in our dataset was ≈ 0.11, and the probability of observing three times the same artifactual variant is very low, p1 ≈ 10-8 (AddInformationormation [see Additional file 1]).
Similar(52)
The variants that arise by mutation or recombination are not transmitted equally from one generation to another.
Natural populations contain large stores of genetic variation, and these are continuously replenished by additional new variants that arise by mutation.
Even methodical selection, Darwin realized, is dependent on variants that arise without regard to human desire.
It joins variants that arise independently within the same molecule, creating new opportunities for viruses to overcome selective pressures and to adapt to new environments and hosts.
Previous reports suggested that there are various FoxP3 mRNA variants that arise owing to alternative splicing of the FoxP3 gene.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com