Sentence examples for variants that altered from inspiring English sources

We found a significant incidence of sinonasal pathology and anatomic variants that altered routine operative planning; therefore, a thorough sinonasal evaluation is warranted in these cases.

During genetic analysis of the SCN5A gene, presence of 3 unknown genetic variants that altered the coded amino acid was noticed in 5 patients.

Similarly, eQTL identified in yeast frequently resulted from genetic variants that altered activity of a signaling or metabolic pathway without directly altering gene transcription [ 17]. 4CL2, F5H, and CCR1 genes involved in lignin biosynthesis map to bin 1.07 [ 1].

We screened the SNPs predicted for HK104 for variants that altered the recognition site of a restriction enzyme, and thus might be amenable to restriction fragment length polymorphism (RFLP) genotyping.

We identified three rare hemizygous variants that altered conserved amino acids in three patients (Fig.  1): c.1289A > G/p.Tyr430Cys was identified in a 10-year-old boy with high-functioning autism and epilepsy, whereas c.1766G > C/p.Ser589Thr and c.1784G > C/p.Ser595Thr were identified in patients with ASD and ID.

Recent efforts to design personalized cancer immunotherapies use predicted neoantigens, but most neoantigen prediction strategies do not consider proximal (nearby) variants that alter the peptide sequence and may influence neoantigen binding.

New techniques in the search for phenotype-associated genes (next-generation sequencing, genome-wide association studies) have expanded the spectrum of both monogenic PD and variants that alter risk to develop PD.

Under such a model, while most variants leading to non-functional transcripts (i.e., noisy splicing) are purged by purifying selection24, genetic variants that alter splicing of immune genes may also be favoured by different forms of adaptive evolution, allowing for a broader repertoire of functional isoforms.

At those loci, we identify candidate genes which, when rendered non-functional, alter those very demographic properties, and in turn, we identify candidate coding or regulatory variants that alter protein structure or gene expression, respectively, being prospective contributors to the variation in phenotype.

Hobbs discovered human genetic variants that alter the levels and distribution of cholesterol and other lipids, inspiring new approaches to the prevention of cardiovascular and liver disease.

Genetic variants that alter the functioning of ERAP1 could, therefore, have proinflammatory effects through this mechanism.