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Patterns of insertions and deletions among twenty-four variantsuggestst a repeating functional unit of Cys-Xaa-Xaa.
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Mutations in the core and the periphery of the protein affect similar aspects of folding for both variants, suggesting a common trajectory with folding of the core region followed by the folding of the periphery.
Noteworthy, the comparison of the isomorphous signal of the electron density maps of the I-CreI variants, suggested a different number of catalytic ions in the active site for the cleavable and non-cleavable targets, even though the configuration of the active sites was similar.
The rapid emergence of CTL escape variants suggests a strong and early CTL response.
Indeed the S5/A variant exhibited a faster recovery curve as compared to WT and S5/E variants suggesting a higher mobility of this variant (96% of recovery twenty seconds after photobleaching) (Fig. 1D).
Thereby, the identification of HPV16 E, Af and NA1 variants suggests a different sexual mixing behavior.
The population diversity of stress resistant Listeria monocytogenes variants suggests a high degree of genetic flexibility [ 52].
In contrast, we were unable to detect complex formation for the R1838A and R1838C variants, suggesting a significant decrease in their relative affinity for the Rock SBD.
The association of leukemogenesis in children with metabolizing gene variants suggests a causal relationship to environmental exposures that may occur during the postnatal period.
The association of SNPs in the CLCN6 gene surviving the adjustment for NPPB and NPPA variants suggests a potentially independent role of CLCN6 in the regulation of NT-proBNP levels.
Detection of these variants suggests a difference exists in the modification states of these tRNAs for the sample analyzed as compared to those already catalogued in the modified tRNA databases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com