Sentence examples for variants sensitive to from inspiring English sources

Identification of genetic variants "sensitive" to specific external signals will open new opportunities for studying the role of genetic and non-genetic factors in complex traits.

On the contrary, rare variants, more sensitive to genetic drift, could well display a discordant LD pattern with common variants among the three populations, explaining the discordant association results.

They inferred that the emergence of a new viral strain after rebound implies that the majority of baseline variants were sensitive to IFN and that the origin of these new strains is uncertain.

However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12.

As both allelic HLA-DR variants are sensitive to adamantyl-mediated ligand-exchange [16], we determined the impact of AdEtOH on these tumour associated antigens (TAA) in vitro, using HLA-DR transfected fibroblasts (Fig. 4A).

These variants are sensitive to NMD and thus are considered as true loss-of-function alleles [ 13].

We show that wild-type TTR and the other common amyloidogenic variants became sensitive to trypsin cleavage under shear stress conditions sufficient to perturb their conformation, thus suggesting that a mechano-enzymatic mechanism may underlie TTR amyloidogenesis.

However, the r 2 (and power of detection) between a marker and a causal variant is sensitive to differences in allele frequency, particularly at low frequencies, suggesting that the allele frequencies of the marker and causative variant cannot be radically different.

The difference in drug sensitivity between CV1 and the 2008 09 seasonal variants (ie: more sensitive to oseltamivir versus more resistance to oseltamivir) is likely due to the specific amino acid substitution (H274N versus H274Y).

The data also show that the phospho form of the V561M variant was less sensitive to all inhibitors with the sensitivity to TKI258 being similar to that observed for the phospho WT (Ki values of 142.0 ± 15.7 and 121.2 ± 5.4, respectively; Supplemental Table 1).

As expected, we observe that both variants are very sensitive to CFO.