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The fluctuation of markets and increasing product variants result in uncertain production volumes.
Under the BIGSdb typing scheme, all gene variations in a dataset (defined by any difference between a gene and any previously recognized gene variants) result in new allelic categories.
We also show that the variants result in reduced protein levels of TBX2.
Human studies suggest that these NOD2 variants result in a loss of function [74].
In vitro transcriptional assays in cultured cells show that both variants result in reduced transcriptional repressor activity of TBX2.
Hilar biliary anatomical variants result in a range of unusual but predictable patterns of segmental atrophy with or without hypertrophy.
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The combination of all variants results in 500 individual scenarios.
Combining the validated variants resulted in 695 exonic SNVs, 88 exonic indels and 1759 SVs.
Progressive accumulation of antigen loss variants resulted in a viral preparation with lower immunogenicity after serial passage.
We show that relatively few mutations introduced in the 46M2 and 46M3 variants resulted in improved binding and neutralization of SUDV and confirmed the importance of the LC FR3 region to the binding interface.
Only 17 TAS2R16 variants resulted in decreased surface trafficking while expressing at near wild-type levels, with most of these mutations (10 of 17) located in TM1 and TM2 (Figure S2b and Supplementary Table S2).
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CEO of Professional Science Editing for Scientists @ prosciediting.com