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Transcript variants result from alternative promoters usage and encode for the same KLK6 protein, since all mRNA sequence changes occur at the 5′-untranslated region, while splice variants result mainly by skipping coding exons and they either encode for small proteins with low identity to KLK6 or to no proteins at all [6, 7].
The cancer-specific ENOX2 transcript variants result from cancer-specific expression of alternatively spliced mRNAs [ 10, 11].
It is reasonable to assume that the different clinical outcomes associated with these NQO2 variants result from their different cellular activities.
Alternative transcription start sites have been reported and, for some intron-containing genes, transcript variants result from either alternative splicing (AS) or intron retention.
The protein chemistry differences that underlie the molecular weight and pI differences that distinguish tissue-specific ENOX2 transcript variants result from alternative splicing of the ENOX2 mRNA [ 27].
UBE2V1 variants result from the co-transcription of UBE2V1 with the neighboring upstream gene, Kua, which shares sequence consensus to fatty acid hydrolases (variant 2, Kua-UEV fusion gene [GI_40806191-I]; variant 4, Kua gene [GI_40806192-I]).
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Column "×" shows that the number of inactive variants resulted from amino acid substitutions.
In this work we aim to take a step ahead in the development of the discipline by introducing a large amount of BFOA variants resulting from the combination of some advanced design decisions applied on Dasgupta et al.'s self-adaptive version.
Analysis of EBV genomic sequences indicated that the majority of EBV miRNA nucleotide variants resulted from post-transcriptional modifications.
An example is given in Figure 3, demonstrating sequenced isomiRs for miR-1, which indicated that the majority of porcine miRNA nucleotide variants resulted from post-transcriptional modifications.
It is possible that the altered catalytic activities of the PEGylated variants resulted from subtle structural perturbations to the enzyme's 3-dimensional fold.
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