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Modulation of CD45 splice variants provides a unique opportunity to design drugs that turn off or turn on antigen and cytokine receptor signaling in cancer, transplantation or autoimmunity.
However, the moderate evidence for some variants provides a rationale for continued research efforts to identify such variants.
Finally, loss of auto-inhibition in filamin splice variants provides a molecular explanation for their enhanced integrin-binding activity.
The list of variants provides a resource for current medaka researchers, in particular those aiming to map and understand the different phenotypes present in these strains.
In contrast, modeling the impact of multiple disease variants associated with immune and inflammatory mediators of allergic asthma (group 1 variants) provides a pseudo-continuous log-normal relative disease risk distribution in the population.
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This study captures up to 98%% of accessible SNPs that have a frequency of 1 % or higher in UK-sampled genomes and with 38 million SNPs and approximately 1.5 million other variants provides an extensive resource of common and rare variants.
This specific distribution of the various Pcnt splice variants provides an explanation for the findings of Miyoshi and colleagues, who reported ciliary defects in the olfactory system of mice with a hypomorphic mutation in the PCNT gene in the region of exon 1, and the absence of a ciliary phenotype in other ciliated tissues like the retina with its photoreceptors.
Our high-resolution structures delineated the altered PAM recognition mechanisms of the AsCpf1 variants, providing a basis for the further engineering of CRISPR-Cpf1.
The characterized scaffold variants provide a standardized framework with defined extracellular environments (microstructure, mechanics) for in vitro studies of the mechanical interactions between cells and scaffolds as well as in vivo tissue engineering studies.
However, a replication in a larger prospective population would be more convinced to affirm whether combinations of risk alleles from these variants provide a better predictive and diagnostic potential in Chinese.
The D154A and I151A FNR variants provide a means to test this possibility.
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