Sentence examples for variants outside the from inspiring English sources
Such modular structures may confer selective advantage by allowing the optimization of gene expression within each module and therefore minimizing the impact of genetic variants outside the module.
Owing to the magnitude of phenotype differences between GK and congenics, which are likely caused by the combined effects of numerous GK variants outside the congenic region in BN.GK-Nidd/gk1 rats, further analyses of insulin sensitivity and in vivo and in vitro insulin secretion, already well-characterized in GK, were limited to BN and congenic rats.
Furthermore, we validated 3 variants outside the highly conserved +1+2/-1 2 +1+2/-1 2es.
After filtering away the variants outside the exome, 20,745 remained for the daughter and 20,901 for the father.
It is also possible that these genes may be implicated in disease susceptibility via regulatory mechanisms involving variants outside the chromosomal boundaries defined for each gene considered.
This is also reflected by the finding that variants outside the C-terminus of GRIN2B occurred significantly more frequently in alleles of EE individuals of Cohorts A and B compared to the EVS controls (p = 0.0027, Fisher exact test).
For example, the transcriptional corepressor Tup1 is highly variant outside of the WDRs among different strains of yeast, but is functionally interchangeable among them [ 64].
Collectively, our current understanding of the genetic basis for individual variations in opioids responses suggests a strong contribution of other untested variables that may include genetic variants outside of the OPRM1 locus or/and the existence of the other functional SNPs within the OPRM1 gene locus and possibly within other yet undiscovered functional elements of the gene.
Although the first 2 studies to monitor potential spread of the swCT variant outside Sweden Ireland and the Netherlandss) did not detect swCT, a third study (Norway) did identify this variant (2 – 4 ).
Our regional heritability analyses did not detect additional susceptibility regions, consistent with the hypothesis that the effects of common variants outside of the 10q24.32/ AS3MT region are likely to be very weak.
However, as all of our significant associations in the present study map to introns or regions downstream from SMS, these results may indicate that genetic variants outside of the promoter region could influence the expression of this gene.
