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Either a single var2csa gene locus encodes a dimorphic series of allelic variants, or multiple loci encode related var2csa-type genes, each having a particular variant of the DSM.
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One interesting cause of heterogeneity occurs when the "heterogeneous" variant is merely a tag for the truly functional variant (or multiple rare variants each with strong functional effects) and the degree of linkage disequilibrium between these variants differs between series leading to weaker and/or opposing effects.
While there are several genetic models for disease susceptibility, the 'rare variant common disease' model largely explains Mendelian heritability (one allele of major effect segregating with familial disease) whereas the 'common variant common disease' model (or multiple rare variants on common ancestral haplotypes) forms the theoretical basis of GWAS [ 46].
Reconciling the needs of each can result in building countless variants, or in piling multiple requirements on a single aircraft.
Most RCTs compared yoga to one control intervention (or multiple variants of the same control condition), but 62 trials (19.4%) specified two or more different control interventions.
The common and well-characterized mutation BRCA1 exon 13 duplication accounts for 8 of these families and 12 families carry variants of either single or multiple exon deletions and duplications.
All cases that were identified as transmission of multiple viral variants or "undetermined" (implying that transmission of multiple viral variants cannot be excluded) were correctly rejected by the Poisson-Fitter through the GOF test.
Under the synthetic associations model, common variant signals reflecting single or multiple rare alleles are unlikely to be consistent across populations of different ancestry.
In the AKAP7 long form splice variants, multiple nucleotide mutations and insertions-deletions have resulted in the concurrent loss of AKAP7γ and formation of AKAP7δ in rats.
This approach enables the resolution of transmission of single or multiple viral variants in nearly all analyzed samples.
To create single mutations or multiple allelic variants, QuickChange XL site-directed mutagenesis kit (Stratagene) was used (The primers and cloning scheme for the different constructs is described in table S3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com