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However, Cas9 orthologues and engineered Cas9 variants offer expanded genome targeting capabilities, improved specificity and biochemical properties.
These new discoveries, along with previously known genetic risk variants, offer an important opportunity for researchers to improve health care.
'Anticalins', engineered lipocalin variants, offer some advantages over traditional antibody technology and illuminate features of molecular recognition between receptors and small molecule ligands.
Such variants offer a particularly elegant implementation with a balanced multipole tree, a feature which might be very favorable on modern computer architectures.
Another challenge will be to show, through well designed prospective studies, that new susceptibility variants offer incremental value in screening and treatment over traditional standards [ 61].
In this regard, NGS-based diagnostics, which are capable of detecting the full range of genetic variants, offer the potential to greatly streamline testing by using a single analysis platform.
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The two plane-casting variants offered comparable quantitative performance.
Table 2 Aggregate number of new automobiles sold, mean number of model variants offered per year, and average number of vehicles sold annually per model variant, by make.
On the other hand, they are also affected, and negatively so, by the number of different model variants offered by each manufacturer.
Although the use of hydroxyproline-deficient variants offers one possibility to overcome this difficulty, these proteins usually differ markedly in stability when compared with the hydroxyproline-containing analogs.
A possible approach proposed by design theory and artificial intelligence research is one of configuring products, i.e. to constrain the set of potential product variants offered to the customer to the possible combinations of pre-designed components.
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