Sentence examples for variants of small from inspiring English sources

Last, common variants of small effect size, modulating the risk for PD, have been identified by genome-wide association studies in more than 20 chromosomal loci.

We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus.

Progress in genomics is illuminating a genetic architecture of schizophrenia that involves a substantial contribution from many common risk variants of small effects (eg, single-nucleotide polymorphisms) but also rare mutations (eg, copy number variants) of large effects.

For example, rare protein-coding mutations of the FOXP2 transcription factor cause severe problems with sequencing of speech sounds, while common genetic risk variants of small effect size in genes like CNTNAP2, ATP2C2 and CMIP are associated with typical forms of language impairment.

Rather, by attempting to identify the countless specific genetic variants of small effects, related to ideology, we hope to uncover and unite larger neurobiological pathways which account for a substantial portion of how ideologies are formed and maintained in a world where both genes and environment interact and remain in continuous dialogue to guide human behavior.

Overall results in the Norfolk pedigree, and Finnish, German and Australian populations suggest that common variants of small effect size in the KCCN3 gene may influence migraine susceptibility.

Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio <1.3) or syndrome-specific variants.

Larger and larger sample sizes have ensured that variants of smaller and smaller effect may be detected.

Population genetic trends of this nature should result in a reduced burden of recessive disorders, and have a favourable impact on complex diseases influenced by partially recessive genetic variants of smaller effect.

Although known GWA results only explain about 5% of the heritability of complex traits, it is at least theoretically possible that common variants of smaller effect size in the population can account for heritability (Gibson, 2010).

We identified 1314 cis-eQTLs at P < 1 × 10−06 and 8 biomarker associations at P < 8 × 10−10, and for cis-eQTLs observed a continuous distribution between lower frequency variants of larger effect and higher frequency variants of smaller effect (Fig.  2 and Supplementary Material, Tables S10 and 11).