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However, short sequence variants of functional importance may change parts of extant cellular genes.
We searched for coding variants of functional significance within six candidate genes in 147 microtia-affected individuals.
A current limitation with regard to recording disease-associated polymorphic variants of functional significance within HGMD is the inclusion of only a single literature reference for each variant.
Note that contigs that fail to align to the reference are still reported by the algorithm, and the variants within them can be explored for variants of functional significance.
Consequently, the beneficial results obtained in this study cannot be considered valid for children suffering from different variants of functional gastrointestinal disorder (IBS-predominant constipation or IBS-predominant diarrhea).
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We have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function.
Diffuse optical tomography (DOT) is a variant of functional near infrared spectroscopy and has the capability of mapping or reconstructing three dimensional (3D) hemodynamic changes due to brain activity.
They found no evidence of an effect of these variants on functional recovery up to 2 years after TKR.
To determine whether R gene SNP variants are of functional significance, further experiments involving transgenic approaches, association genetic analysis or map-based cloning are required [ 72, 73].
An alternative study design such as large collaborative case-control studies [ 35], or pooled family studies assessing risk associated with variant of similar functional capacity, may be required to provide better estimates of cancer risk associated with variants of intermediate functional phenotype.
This analysis indicated that either cancer-associated nsSNPs may not necessarily fall into evolutionary highly conserved positions, or the distribution may be skewed towards a lower conservation level by cancer variants of no functional consequence (passenger mutations).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com