Exact(1)
The unique features of the variants observed here suggest the importance of isoforms of catecholamine transporters in monoaminergic signaling in the brain and peripheral tissues.
Similar(59)
Epigenetics has been identified as mechanism in T-cell lineage commitment [32], [33], and could therefore explain the ambiguous variant phenotype observed here.
However, it cannot explain the difference in the signaling characteristics of GDF-5 (or its variant R57A) observed here between the two cell lines C2C12 and ATDC5 or between the heterotopic and orthotopic ossification model, because we have to assume that the ligand-specific differences in the receptor architecture are identical in both cell lines and in both tissue environments.
It is possible that during the process of RPE transdifferentiation the alternative splice variants of pax6 observed here have different functions or different gene targets.
However, even if the true effect estimate was half the size observed here, the genetic variants would still explain >10% of AMH variability in males.
The small effect size seen with the fracture-associated variants indicates that future studies will need to be adequately powered to detect variants with odds ratios lower than those observed here, and will thus need to be extremely large.
A lower redox potential is accompanied by a decrease of the bimolecular rate of the reductive half reaction, as observed here for PDH variant H103Y.
An informative comparison of the SFs observed here with the frequencies reported from previous studies is challenging because the list of genes, variant classification databases and interpretation of clinical significance are evolving.
Property lines are not really observed here.
The same trend was observed here.
However, such changes are not observed here.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com