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In view to probe the lipid binding properties of the wheat nsLTP1, mutant variants may represent a powerful tool.
Although some sequence variants may represent SNPs, these data are consistent with recent reports that a significant fraction of such sequence variants are "passenger" rather than "driver" alleles and underscore the importance of functional assessment of candidate disease alleles.
These variants may represent "the genetic essence of humanity," says Stephan Sanders, a geneticist and pediatrician at the University of California, San Francisco, who was not involved in the study.
Moreover, our data suggest that inhibitory, ILT4-mediated immunoregulatory effects of CTL epitope escape variants may represent a relatively common and previously underestimated biological consequence of HIV-1 sequence diversification.
While key causative polymorphisms await definitive identification through replication studies and functional characterization, this and previous findings strongly suggest that NPSR1 genetic variants may represent common risk factors for chronic inflammatory conditions such as RA, asthma and IBD.
However, many of these low frequency variants may represent neutral variation.
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A subsequent study noted the same mutation in 3 of 114 patients with TOF as well as in two African-American control subjects indicating that the variant may represent an ethnically restricted susceptibility variant over-represented in patients with TOF [ 26].
The production of the Lys114Tyr variant may represent an improved catalase suitable for industrial purposes.
Therefore, the 102 bp variant may represent an evolutionary intermediate of centromeric repeat in Coix.
The P479L variant may represent an underlying vulnerability (i.e. a predisposition to hypoglycemia) that, when combined with exogenous stressors during a critical development period and/or intercurrent illness, may increase risk for unexpected infant death.
Hypothesizing that the strong genetic association may indicate a causal relationship and the TCF4 genetic variant may represent a tissue-specific regulatory element, TCF4 mRNA studies in corneal endothelial cells were performed.
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