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Although the ITvar9 antibodies generated here appear to be strain-specific, this cannot be generalized across all rosetting variants without further study, and our preliminary data suggest that other rosetting PfEMP1 variants may induce cross-reactive antibodies (Ghumra and Rowe, unpublished data).
Findings in EHTs rather indicate that the genetic variants may induce hypercontractility, which suggests a gain-of-function effect.
Similar(58)
Independent evolution of viral variants in the MGT may induce the formation of variants that harbour the ability to escape the effects of immune system and drugs, vary tropism and pathogenicity.
Therefore, m-spinesin variants may have distinct biological functions arising from organ-specific variant expression.
Variants may have pleiotropic properties.
Furthermore, the NMR analysis of homomeric polyproteins of this variant suggests that these constructs may induce slight structural perturbations in the monomer, which may explain some minor differences in this variant's properties; namely the abolishment of the mechanical unfolding intermediate and a reduced thermal stability.
Low enzyme activity of MTHFR C677T variant genotypes are associated with DNA hypomethylation, which may induce genomic instability and thereby affect the expression of oncogenes or tumor suppressor genes.
Finally, peptide-based vaccinations may induce the generation of tumour escape variants lacking the expression of a particular peptide epitope (Pawelec, 1999).
These results further imply that binding to the client may induce the folding of the very unstable Spy variants such as L32P.
Therefore, we supposed that genetic variant of ITPKC may contribute to influence the calcium influx and, furthermore, may induce the activation of T cells which provoke inflammatory reaction.
One optimistic view is that a single clade may induce sufficiently cross-reactive T-cell responses to protect against other variants of both the same and heterologous clades.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com