Sentence examples for variants may impact from inspiring English sources

We highlight the discovery of a polymorphism in TOMM40 that, in addition to APOE, may improve risk prediction and review how TOMM40 genetic variants may impact the develop of LOAD independently from APOE.

Based on the central role of serotonin in the pathophysiology of CH and these previous findings, it is plausible to hypothesize that further genetic variants may impact pharmacological effects involving the serotonin system and thus triptan response.

While there is currently no evidence to conclusively demonstrate that these variants may impact translation dynamics for complex I (and thereby alter the bioenergetic system of the neural and vascular retina), our results provide a reasonable basis for examining this possibility.

These variants may impact the efficacy of the drugs they metabolize.

A recent review summarizing association studies in 15 different plant species also implicated Robertson's model and further suggested that phenotypic traits, species, and types of variants may impact distributions of effect sizes [ 64].

By showing that DISC1 amino acid substitutions associated with psychiatric illness affect its regulatory function in ATF4-mediated transcription, our study highlights a potential mechanism by which these variants may impact on transcriptional events mediating cognition, emotional reactivity and stress responses, all processes of direct relevance to psychiatric illness.

CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice variants which may impact hyaluronan binding.

This finding is interesting because it suggests that the link between selenium and depression may be impacted by individual factors, such as genetic variants that may impact the selenium levels in the body.

The CACNA1C intron 3 variant rs79398153 may impact CACNA1C gene expression by virtue of its presence in an ENCODE-marked transcriptional enhancer region.

To understand how splice regulatory variants may ultimately impact organismal traits, we searched for overlaps between sQTLs and loci associated with complex traits or diseases by genome-wide association studies (GWAS 46.

Considering variants jointly models the biological reality that a number of different variants may separately impact the functioning of a gene.