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In addition, many common variants may contribute risks that are too small to have shown up in current surveys, he said.
Based on this intersection, we propose that, although strong or inactivating mutations (rare variants) in these genes may cause severe disease (PIDs), their more subtle modulation potentially by common regulatory/coding variants may contribute to chronic inflammation.
Given the variety of NEP target peptides and their wide expression pattern, it is plausible that MME deleterious variants may contribute to the aetiology of different neurological conditions, and further studies are needed to identify the mechanisms underlying the phenotypic differences.
Both common and rare variants may contribute to complex diseases.
Moreover, ankyrin-B variants may contribute to sudden cardiac death among young athletes.
Rare germline EPHB2 variants may contribute to a small fraction of hereditary colorectal cancer.
Similar(20)
Nevertheless, combined results from the two independent recruiting sites indicate that the ENT1-216Thr variant may contribute to the risk of alcoholism with withdrawal seizures in humans.
Whilst, it can not be ruled out that this rare GHSR promoter variant may contribute modestly to the pathogenesis of obesity it would require a much larger study sample to investigate this.
Therefore, it is possible that this variant may contribute to the phenotype of variant carriers.
This observation is consistent with the original study that this variant may contribute to the risk of ECD.
These findings suggest that the TS 3'-UTR variant may contribute to the etiology of breast cancer in our Chinese population.
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