The minor T variant may change a transcription binding site for a co-repressor, leading to lower expression of the AHSG protein and thus significantly lower fetuin-A levels.
Comparing the estimated kinetic parameters of a reaction in the wild type and mutant cells permits quantification of the effects of genetic variants, which may change the abundance or activity of a metabolic enzyme.
A variant SNP may change a gene's coding for its protein product, leading to a protein with different properties.
Consequently, it appears that the rabies viruses might be circulated among bat populations inhabiting in contiguous areas, and although the variant distributions may change slowly over time, natural barriers such as mountain ranges may play an important role in delimiting rabies foci, resulting in regionally-differentiated rabies virus variants.
A possible confounding factor in the present study is that, within a study group, the frequency of individuals carrying a determined variant allele may change with age in the event that the presence of such allele would be related to severe diseases.
However, the presence of genetic variants may markedly change the situation [ 31].
However, short sequence variants of functional importance may change parts of extant cellular genes.
If this is the case, the over-representation of these DMCs or DVC in obesity GWAS genes will indicate that these genes are very important for the etiology of obesity in which either sequence variants or epigenetic variations may change the gene functions and contribute to obesity.
Currently, prospective LN risk prediction based on sequencing the genome for rare and common variants is not yet feasible due to the limited predictive power of all associated variants known today, but this may change in the near future.
Indeed, as clinically important variants are discovered, the paradigm may change to sequencing small panels of genes that are known to be relevant to disease, as is common in cancer genomics.
