As the error rate (i.e. number of flipped variant calls) increases, some variant calls may become consistent with a different haplotype of higher accuracy.
As the field transitions to whole-genome sequencing in place of genotyping, in an effort to identify rare-variant eQTLs, data access issues may become more problematic, necessitating a reliance on repositories that provide summary statistics [ 26].
But as researchers pool data from thousands of cancer gene tests, some of those benign variants may be reclassified as dangerous, or may become informative in ways that hadn't been anticipated.
Novel population-specific or ancestry-informative variants may be identified, and more eQTLs that contribute to genetic variation of ancestry informative GE may become available.
Issues of distributive justice may become less pressing once genetic variants become more widely used in multiple preventive programs.
For an individual with high pre-test risk, variants that are 'low risk' for the average person may become important.
In other cases, a variant may be pathogenic when inherited as a recessive trait but may become a susceptibility factor for other neurological conditions at the heterozygous state.
When the number of variants involved is large, e.g., several dozens to hundreds, the exhaustive grouping strategy may become computationally prohibitive.
This trend may become stronger with a larger cohort of PTLD individuals carrying the variant allele.
From a biological standpoint, extremely low heteroplasmic variants, being these potentially pathogenic or not, may rarely have a physio-pathological meaning (unless they may become amplified during transmission to offspring).
