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The influence of genetic variants may affect this relationship.
The data further emphasize the interdependent nature of these physical bone traits suggesting similar genetic variants may affect both trabecular and cortical bone.
Hereditary genetic variants may affect a drug's pharmacokinetics or pharmacodynamics and account for differences in treatment response and adverse events among patients.
Also, other functional variants may affect the expression of PRNP and therefore carrying out confirmatory studies in these loci or other polymorphisms using the same tissue or other tissues in other populations would be useful.
PGx variants may affect one's response to a drug through influencing either PK or PD machinery.
Although intronic variants may affect splicing functions, they do not affect coding regions per se.
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The binding specificity for each receptor variant form may affect the potential for different viruses to cross the species barrier or make the difference between causing severe or only mild disease.
Since GC is observed in some intron donor sites, it is hard to predict if this variant may affect splicing.
Residue 9 (rs1059046, T9N) is located in the signal peptide, and it is unknown whether this variant may affect the protein.
The important role of both domains in tyrosine kinase activation and Dok-7 signaling suggests that the variant may affect MUSK signaling and AChR clustering.
The N-terminus of CXCR1 protein has been identified as potentially important for receptor ligand binding, leading to the suggestion that the M31R variant may affect this interaction.
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