Examination of the chromosomal location of rupsC related variants revealed that these are the only variants located in proximity to the centromeres.
Initially, we looked for homozygous variants located in the shared runs of homozygosity (ROH).
A total of 193 non-psychotic males (117 methamphetamine-dependent and 76 controls) were genotyped for variants located in six genes (AKT1, ARRB2, BDNF, COMT, GSTP1, OPRM1).
Overall, DNA variants located in exons and exon-intron boundaries were rare.
This important cytokine is up regulated following radiation exposure and common variants located in TGFB1 have been found to be associated with late normal tissue complications [13] [17].
In the single tSNP analyses, our primary associations with BP variation and EH were observed with variants located in the WNK1 promoter regions and intron 1.
In our exploratory phase, we report associations of variants located in the MEFV 5' region with both CD and UC in Belgian samples, yet we failed to subsequently validate these associations in the Canadian and Scottish additional sample sets.
These results allow us to exclude the hypothesis that the common variants located in the exons, intron-exon junctions, promoter and regulative regions of the VEGF gene may have a causal effect on the VEGF variation.
We examined these variants located in or near the JAZF1 (rs864745), THADA (rs7578597), TSPAN8 (rs7961581), ADAMTS9 (rs4607103), NOTCH2 (rs10923931) and the CDC123/CAMK1D (rs12779790) genes for associations with measures of pancreatic beta-cell function and insulin sensitivity.
Minimum detectable effect size with a statistical power of 80% was calculated for each SNP in all studied samples and linkage disequilibrium was assessed between genetic variants located in the same locus (Table S2).
3. Synonymous variants: variants located in exons that do not change the translated amino acid sequence.
