Sentence examples for variants lie in from inspiring English sources

Furthermore, most of these associated variants lie in non-coding regions, so their functional effects have remained undefined.

Although targeted resequencing utilized for the identification of causal variants has discovered coding mutations in some AD-associated genes, a lot of risk variants lie in noncoding regions.

Some of the remaining challenges for scientists searching for causal disease variants lie in: accessing data derived from cell types and tissues relevant to the disease under study; understanding how these functional units affect genes that may be distantly located7; and the ability to generalize such results to the entire organism.

These 130 homozygous LOF variants lie in 125 genes.

Specifically, all three variants lie in regions of open chromatin in MCF7 cells (Fig.  2A).

Most of the known and novel variants lie in intergenic regions.> -wrap-foot> $Legends to the class types.

It is tempting to speculate that any difference in oncogenic potential between the two variants lies in the different phosphorylation potential of eEF1A1 and eEF1A2.

rs4444235 and rs9929218 are two variants lying in the near-by and intronic regions of BMP4 and CDH1, respectively, that have been recently reported to be associated with the disease [8].

The 28-kb risk haplotype consisting of intronic variants lies in the middle of the ADAM23 gene.

We also removed variants lying in genes that have emerged as hyper-variable in published exome-sequencing studies in some analyses.

Genome-wide association studies have also highlighted the evolutionary significance of noncoding sequence, finding as much as 88% of trait-/disease-associated variants lies in noncoding sequence (Altshuler et al. 2008; Hindorff et al. 2009).