From this list, we excluded all the synonymous variants, which led us to a final number of 25 variants (Supplementary Material, Table S1).
My interest in centromeres and surrounding heterochromatin began with a suggestion from my postdoc mentor, Charles Laird, to look into the classical phenomenon of position-effect variegation, and our later interest in histone variant evolution led us to explore this final frontier of the genome.
The observation that tau and axotrophin RING-variant domain interact led us ask, whether the E3 ubiquitin ligase activity of the axotrophin RING-variant domain can induce ubiquitination of tau.
The large number of histone variants expressed in testes led us to investigate their retention in mature sperm.
Sequence-specific hybridisation probes provide the most specific real-time analysis of amplified target sequences but the very high variability of HIV sequences within subtypes, even in HIV variants in a given patient, led us to choose a sequence-independent detection with SYBR Green I.
In Ms. Anderson's case, vocal architecture served as a metaphor for life in all its variants of struggle and victory; it led us to the character, or at least this singer's vision of her.
However, the team found examples where inherited variants led to the appearance of specific acquired mutations later in life or gave cells with such mutations a growth advantage over other cells.
The development of the LS 460 and its variants, led by chief engineer Moritaka Yoshida, began as Lexus was shifting its design strategy towards a more diversified product lineup, with new-vehicle launches largely focused on global markets.
Moreover western blotting indicated that all mutated variants led to protein secretion (Fig. 3B) even though MMP-2 C233A had no MMP-2 activity (Fig. 3A).
We showed that these variants led to mitochondrial metabolite imbalance, and in turn cause stabilization of HIF1α, and decreased baseline p53 levels mediated by the noncanonical NQO1 pathway.
