Sentence examples for variants lacking the from inspiring English sources

In a preclinical mouse vaccination model, these QS saponin tucaresol conjugates induced antibody responses similar to or slightly higher than those generated with related QS saponin variants lacking the tucaresol motif.

MutSalpha variants lacking the PCNA interaction motif are functional in 3'- or 5'-directed mismatch-provoked excision, but display a partial defect in 5'-directed mismatch repair.

We find that MEF2C variants lacking the γ-domain are particularly sensitive to activation by membrane depolarization, raising the possibility that the MEF2s may differentially contribute to activity-regulated gene expression.

These truncated variants lacking the extracellular part of the wild-type protein (Supplementary Data S5) are similar to the constitutively active variant I of EGFR (EGFRvI) [19].

Unexpectedly, we also found that poly-I/C stimulated the ATPase of RIG-I variants lacking the C-terminal RD, in strong contrast to either pppssRNA or heteropolymeric dsRNA (fig 6).

If ΔdinB strains expressing DinB variants lacking the β-clamp binding motif are as sensitive to either MMS or NFZ as ΔdinB, then it could be inferred that the observed enhanced sensitivity is mediated through interactions with the β-clamp, and is consistent with the idea that these DinB variants are localized at the replication fork.

Full-length spinesin (type 4) and type 3 contain all the domains, whereas type 1 and type 2 variants lack the cytoplasmic, transmembrane, and scavenger-receptor-like domains.

It is known that splicing variants lack the α site function as a dominant-negative inhibitor of telomerase (Colgin et al, 2000; Yi et al, 2001).

DOI: http://dx.doi.org/10.7554/eLife.03145.023 Electrostatic calculations for the R971A and D407N crystal structures indicate that, like K940A and D408N, these variants lack the ability to bind and release two protons.

Although, clearly, the resulting protein variant is mouse-specific, it was noted that the alternative C-terminus variant of GBP-5 exists in humans (AF328727) and that both mouse and human variants lack the C-terminal CaaX isoprenylation motif [ 29, 30], which might be of physiological importance.

We present three-dimensional reconstructions of the different architectures of G40P hexamers and a variant lacking the N-terminal domain.