Sentence examples for variants is mediated from inspiring English sources

Most importantly, the diabetogenic variants of four loci (TCF7L2, ADRA2A, KCNJ11, and KCNQ1) were associated with reduced insulin exocytosis or altered insulin granule distribution in isolated β-cells, which implies that part, if not most, of the diabetogenic influence of these risk variants is mediated through alterations in single β-cell function (74).

All substrates tested were not degraded in the presence of inactive protease variants, thus excluding that the substrate degradation by active variants was mediated by impurities in the preparation.

Mechanistically, we found that the deleterious effects of C2238/ αANP variant are mediated by a deregulated activation of the type C natriuretic peptide receptor (NPR-C) with a consequent decrease of cAMP levels and PKA activity.

The minor C-allele of rs2237895 of KCNQ1, which has a prevalence of about 42% among Caucasians was associated with reduced measures of insulin release following an oral glucose load suggesting that the increased risk of type 2 diabetes, previously reported for this variant, likely is mediated through an impaired beta cell function.

The transfer and deposition of histone variants into chromatin is mediated via their association with specific histone chaperones.

In the prototype EAEC strain 042 carrying the AAF/II fimbriae variant, this binding is mediated by AafA protein.

Assuming the association between FGFR2 variants and breast cancer is mediated through breast density, one would expect to see a 33% difference in mammographic density comparing homozygous variants with homozygous wildtypes.

Tissue damage in variants of Guillain Barré syndrome is mediated by anti-ganglioside antibodies (Rinaldi and Willison, 2008), but even if present in the samples we analysed, their specific targets were not expressed in these myelinating CNS cultures.

Together our results suggest that any influence of the rs1051730 variant on birth weight is mediated by maternal smoking behaviour.

The probability of pathogenicity of radical variants should depend on whether disease is mediated by loss or gain of function of the gene of interest.

The molecular mechanism, by which the heterozygote advantage of Indy on fecundity and longevity is mediated, in both variants in the wild and through experimental manipulations in the laboratory [ 4, 6], involves modulation of Indy transcription.