The difference between the medium and high variants is almost 300m extra people between now and 2050.
The diversity of Stylonychia histone variants is almost double that of T. thermophila (12; proteins from ciliate.org, November 26, 2013, possessing the Pfam core histone domain).
The meta-analysis of ADHD GWAS, which involves hypothesis-free testing of thousands of genetic variants, is almost certainly underpowered to detect effects.
Over time, the transparent variants predominated in low biofilm forming strains, reaching almost 90% at day 4. On the contrary, for high biofilm forming strains, the proportion of transparent variants was always below 50%, and by day 7 the percentage of the opaque variants was almost 90% (Figure S1).
Four TFBS (C/EBPalp, AP-2alpha, SP1, Oct1) are present in all the analyzed species; moreover, the NF variants are almost ubiquitous.
Expression of the SOD3 variants was almost 10-fold lower than both SOD1 and SOD2 expression in both sexes of Oregon R wild-type Drosophila.
For instance, the four clearly pathogenic MEFV variants are almost exclusively found in Mediterranean populations, while the frequency of the debated p.Glu148Gln (NM_000243.2:c.442G→C) variant is as high as 20% in Asiatic countries.
By contrast, radical variants are almost absent from the general population, so that for many inherited cardiac conditions such a variant in a patient is conventionally considered pathogenic [ 5].
The identified variants were almost all non-synonymous substitutions, but follow-up studies on additional unrelated samples using Sanger sequencing also identified insertions/deletions in the same genes (33, 35).
As observed with HeLa X1/6 cells, the dox-induced activity of the new sc-rtTA variants in C33A cells is higher than that of the wild-type sc-rtTA, and the new variants are almost as active as the regular rtTA, while the background activity is not affected by the introduced mutations.
Simulation results suggest that causal estimates obtained from summarized data using a likelihood-based model with independently distributed 'non-weak' variants are almost as precise as those obtained from individual-level data, with bias close to zero and coverage close to nominal levels.
