Sentence examples for variants in zebrafish from inspiring English sources

Using a combination of bioinformatics, molecular cloning, and phylogenetic analysis, we identified conserved orthologs of all 4 mammalian β subunit genes and 8 novel β1 and β2 splice variants in zebrafish.

Our analysis of the GREM2 variant Q76E and the cardiac imaging approaches developed here provide a template for functional modeling of AF-associated variants in zebrafish and differentiating embryonic stem cells.

To investigate the biological significance of Mef2ca and Mef2cb splice variants in zebrafish embryonic development, we determined the effects of their ectopic expression by injecting embryos at the one-cell stage with synthetic Mef2c mRNAs and analyzing them at 24 hpf.

Expression of the patient-specific ALK2 L343P variant in zebrafish showed that this results in a malformation of the AV canal and compromised expression of endocardial cushion markers.

RT-PCR analyses suggested that at least two splice variants exist in zebrafish gmds, with or without exon 4, which we name gmds-L and gmds-S respectively.

Fig. S6 Effects of Mef2ca splice variants overexpression in zebrafish embryos.

Similar to in mammalian systems, Hif-3α has multiple splice variants in the zebrafish and is not as widely studied as Hif-1α and Hif-2α (Zhang et al., 2014).

Nonetheless, the validation of strumpellin mutations (Valdmanis et al., 2007) has allowed the development of a patented diagnostic test for HSP that is licensed to Athena Diagnostics Inc., emphasising the usefulness of variant validation in zebrafish.

These results emphasize the conservation of variant function between the two species, and indicate that a much higher number of variants can be analysed in zebrafish than is feasible in the mouse.

Nicholas Katsanis (Duke University, USA) presented an elegant approach to resolve the functionality of candidate genes and variants using morpholino-induced translation suppression in zebrafish.

The same variant as in chicken is present in zebrafish, however NDEL1 and MYH10 genes are separated.