In recent years, DNA variants in two different genes have been linked to how much blood thinner a patient needs.
The researchers found that common variants in two genes previously linked to Parkinson's disease, LRRK2 and RAB7L1, led to an unexpectedly similar impact on human brain tissue.
We genotyped ∼200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip).
Family studies have suggested that 10 to 40percentt of the variation in sleep duration may be inherited, and previous genetic studies have associated variants in two gene regions with sleep duration.
We investigated the association of variants in two candidate genes that are important in CSF production, aquaporin 1 (and1) and solute carrier family 4, sodium bicarbonate transporter, member 10 (SLC4A10), with POAG in the Caucasian population.
And just last month, researchers found that variants in two genes could account for the increased suicide risk associated with antidepressants (ScienceNOW, 28 September).
The Einstein team has identified, for example, variants in two genes associated with increased levels of high density lipoproteins (which have a protective effect on cardiovascular health in this population).
To see if their findings were just a fluke, they tested those same genetic variants in two other large groups -- Americans in the Women's Genome Health Study and Icelanders working with scientists at DeCode Genetics.
Variants in two genes postulated to play a role in viral and HPV binding, OAS3 and SULF1, were also associated with HPV persistence in our population.
In the U.S. sample, we identified two novel non-conservative RTN4R coding variants in two patients with schizophrenia that were absent in 600 control chromosomes.
To determine whether CRY2 genetic variation is associated with depression, we analyzed circadian clock gene variants in two separate population-based samples, a Swedish sample and a Finnish sample, and report that the CRY2 gene is associated with winter depression.
