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Common variants in these evaluated genes do not appear to be strongly associated with EOC risk.
Furthermore, the putative functional variant or variants in these loci mostly remain under investigation.
The difference of over 100 kb in distance accounts for the reduced power of WES to identify variants in these regions.
They identify low-frequency coding variants in IL23R that confer protection against inflammatory bowel disease but conclude that rare coding variants in these positional candidates do not make a large contribution to Crohn's disease risk.
Given the consistent findings across different-ethnic groups, further studies are warranted to perform investigations of functional genetic variants in these regions.
We hypothesized that common variants in these genes associate with risk.
It may be that variants in these genes result in the development of MRM.
The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk.
Polymorphic variants in these same genes in the human population may be the elusive genetic risk factors for heart failure.
CONCLUSIONS This report adds to accumulating evidence that at least some variants in these genes are associated with an increased risk of breast cancer that is clinically important.
By deep sequencing, the median percentage of non-R5 variants in these patients rose from 1.4%to99.5%5% after a median of 4 weeks on maraviroc.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com