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From then on, it has found many different applications and variants in several fields, such as ecology, physiology, combustion, general phase transition problems.
We evaluated the RV-RabG variants in several animal models (mice, dogs, and pigs) and demonstrated that a single dose elicited high titers of rabies virus-neutralizing antibodies and protected animals from live rabies virus challenge (mice and dogs).
This was the case for all three macroH2A variants, in several cell types.
However, with our approach we did find consistent association to genetic variants in several independent samples for MC5R, DYM and NEDD4L.
Genetic variants in several genes are known to influence BMI, but these mutations are rare and often cause severe monogenic syndromes with obesity [4].
This study is aimed at investigating the implication of UTS2 gene variants in several traits related to T2DM in the Spanish population.
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In this study we evaluated the role of this variant in several models: allelic, additive, dominant and recessive.
The initial suspicion of "something strange" may be from clinicians who investigate outbreaks (e.g., a sudden increase in the number of reports), or from one of the laboratories (e.g., finding the same variant in several outbreaks).
Dot-blot hybridization and TRAP results suggested a synthesis of the human-type variant in several species from the Dunaliellinia clade and gave an unclear pattern of occurrence of minisatellite repeats in the Stephanosphaeria clade.
The c.1691G > A alteration (called the Leiden variant) has been reported to be associated with resistance to degradation by activated protein C. Since then, numerous studies have examined this variant in several conditions that correlate with thromboembolism, but the results were inconsistent regarding the pathological role of this alteration [ 34- 37].
Via exome-sequencing, genes harboring variants implicated in several Mendelian traits have already been identified.
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