Sentence examples for variants in relation from inspiring English sources

However, as the number of patients and genes increase, the interpretation of novel sequence variants in relation to the related phenotype becomes a major challenge.

We examined 172 apoptosis-related sequence variants in relation to PCA risk and disease aggressiveness, as shown in Tables 2 and 3. Age and family history of PCA did not modify the relationship between the sequence variants and the risk of developing PCA or aggressive disease.

However, to date no study has investigated MMP8 gene variants in relation to chronic periodontitis (CP).

We aimed to examine the potential effect of these variants on fetal body composition by investigating the variants in relation to birth weight and ponderal index of the newborn.

A post-transcriptional stabilization of AR splice variants in relation to the ARfl in selective CRPC bone metastases is therefore plausible, although the mechanism for this is not known.

There were no statistically significant differences between cases and controls for any of the 53 combinations of SNPs that we observed in either ethnic group (table 3 and fig. 2) We went on to investigated the role of TIRAP variants in relation to disease manifestations by comparing the frequency of each variant in patients with pulmonary compared to disseminated TB.

In addition, we performed a meta-analysis of the rs6983267 variant in relation to risk of colon and colorectal cancer.

If the meta-analysis revealed a positive association between a given genetic variant and diabetic nephropathy, and more than ten studies investigating that variant in relation to diabetic nephropathy were available, a meta-regression was performed.

The most frequently evaluated variant in relation to cancer risk is the single nucleotide polymorphism (SNP) at codon 148 of exon 5 of the APE1/Ref-1 gene (i.e. Asp148Glu; D148E; rs1130409).

Another strength of our study is the homogeneity of population that allowed us to effectively evaluate vitamin D and the VDR gene variant in relation to cardiovascular risk factors, severity of CAD, and collateralization.

Data for the rs1042522 and rs1625895 (rs1625895, intron 6, G>A, PIN6 (polymorphism in intron 6)) variant alleles in relation to cancer risk was also compiled and analysed from the same publication set to assess their potential confounding effect.