Sentence examples for variants in only from inspiring English sources
Our approach, which involved polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis and direct sequencing, revealed nucleotide variants in only two of the 108 specimens.
The observation of such variants in only one of the W-Beijing strains is most interesting, and consistent with recent observations that the pathogenic characteristics of W-Beijing strains are not conserved, with strains within individual W-Beijing lineages having evolved unique pathogenic characteristics [16].
Sequencing detects variants in only 70%75%% of individuals with definite LQTS.
We detected variants in only two of 20 PHP1b index cases (albeit with different extents of sequencing).
Sequencing revealed some known and some new common variants but identified rare heterozygous amino acid-changing variants in only three out of 96 patients.
Unlike PCD, where multiple genes are implicated in the disease mechanism, variants in only few genes are currently known to cause isolated, non-syndromic laterality defects.
Informal polling of many human geneticists suggests that exome sequencing projects currently identify a truly causative variant in only about 10%to50%0% of cases, although this estimate is very rough given that most researchers do not publish their results (or lack thereof) when exome sequencing fails to identify a causative variant.
The number of uniquely observed variants, i.e. variants called in only one replicate, is in the range [118 252] and [29395 54746] for NA12878 WES and WGS, respectively, and [182 335] and [66342 104224] for NA18507 WES and WGS respectively.
The majority of these nominal allele sequence variants displayed a low frequency of occurrence across the dataset, with 16 of the 19 allele variants detected in only one single sample each.
In each experiment, the authors used mRNA from just 50 neurons from the brains of people with or without sporadic Alzheimer's, because averaging across large neuronal populations could mask variants present in only a few cells.
The tagA gene was one of the most conserved genes in our panel, with ns variants found in only two strains.
