Sentence examples for variants in important from inspiring English sources

In conclusion, we identified several biologically plausible associations between genetic variants in important inflammation-related genes and risk of developing esophagitis and pneumonitis.

Furthermore, rare variants in important genes may have crucial effects that cannot be quantified by traditional genome-wide association methods [ 17].

Initial data from the first 900 samples revealed many novel and rare variants, including newly described truncating variants in important pharmacogenes such as CYP2C19 and DPYD.

To efficiently identify those with significant biological functions, a practical strategy is to concentrate on variants located in important sequence regions such as gene regulatory regions.

Here we investigate genetic variants in genes important for neurobiological pathways linked to suicidal behaviour and/or associated endophenotypes, for association with SA among patients with co-existing psychiatric illness.

Hereditary recurrent fevers (HRFs) are a group of monogenic autoinflammatory diseases characterised by recurrent bouts of fever and serosal inflammation that are caused by pathogenic variants in genes important for the regulation of innate immunity.

Ongoing projects are: targeted re-sequencing in pharmacogenetic breast cancer and hypertension studies, platelet RNA sequencing in responders and non-responders to clopidogrel, and RNA sequencing in tissues of major pharmacologic interest to assess gene expression levels of common splice variants in very important pharmacogenes (VIPs).

This would hint that the observed variants are located in important regions for protein function.

A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2.

Genetic variants in HDACs are important determinants of susceptibility to cardiovascular diseases, 32 suggesting functional roles for HDAC4 in modulating perioperative myonecrosis, and their potential use in predicting individual patient responsiveness to HDAC inhibition.

Here we test the hypothesis that genetic variants in candidate genes important for neurobiological pathways linked to suicidal behaviour and/or associated endophenotypes, may confer a protective [ 22] or risk effect on SA among patients with co-existing psychiatric illness (suicide attempters versus non-attempter controls).