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Furthermore, the system detected feline BDV variants in five naturally infected cats and a feline isolate used in experimental infection of cats.
Consistent with the branching topology, the distribution of maximum env pairwise distances suggested transmission of multiple viral variants in five subjects, A, OG, OW, PP, and PK.
Thus, branching length and topology of gag sequences was consistent with transmission of multiple viral variants in five (20%) cases (subjects D, OG, OW, PK, and PP), undetermined multiplicity of transmission in five (20%) cases (subjects A, E, F, OJ, and QP), and transmission of a single viral variant in 15 (60%) cases.
Inherited variants in five of the fetuses are possibly causal.
In this way, a mean of 13 variants in five genes was identified per patient.
Fifteen variants in five genes passed this series of exclusion criteria (Table 1).
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One research team, led by Juliane Winkelmann and Thomas Meitinger at the Institute of Human Genetics in Munich, reports in Nature Genetics today that it has found variants in three genes that confer risk for restless syndrome.
PolyPhen-2 categorizes the variants in three groups: benign, possibly damaging, and probably damaging.
FHM belongs to the group of channelopathies and multiple genetic variants in three different genes coding for neuronal ion channels have been identified as causative.
We report 17 individuals with pathogenic variants in seven of the 27 genes, defining a genetic etiology in 3.2% of this unsolved cohort.
We genotyped ∼200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip).
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