Sentence examples for variants in combination from inspiring English sources

As the arginine biosynthetic pathway is naturally regulated by feedback inhibition of N-acetylglutamate kinase (encoded by argB) by arginine, the use of feedback resistant enzyme variants in combination with deletion of argR has been described to overproduce L-arginine (Sakanyan et al. [1996]; Ikeda et al. [2009]; Schneider et al. [2011]).

A possible novel protective effect of TNFRSF6B genetic variants, in combination with two other genes, was suggested however, this was not confirmed by a larger cohort study [14].

Hence, investigating the effect of these variants in combination with other genetic variants or environmental factors would help elucidating their potential role in NAFLD.

The presence of these BCL10 and TRAF6 binding sites in some of the MALT1-API2 fusion variants in combination with the RING E3 ubiquitin ligase domain of API2 suggests that these MALT1-API2 proteins could bind BCL10 and/or TRAF6 and mark them for ubiquitination-induced degradation.

Additionally, it would be interesting to examine the variants in combination with other MMR gene variants.

Some genetic variants in combination with specific HT may increase MD in susceptible women.

Two promoters, elongation-factor-1-short-form, and a myeloproliferative sarcoma virus variant in combination with two commonly used envelopes were comparatively assessed choosing enhanced green fluorescent protein or a third-generation chimeric antigen receptor (CAR) against CD123 as gene of interest.

We investigated the −41 bp variant in combination with rs143383 and rs143384.

There are a number of gene-environment interaction studies where the effect of the short variant in combination with stress has been examined.

If, however, it turns out that digenic and oligogenic conditions are more common than originally anticipated, then many disease contributory variants will have evaded purifying selection, and hence those variants that in combination (but not individually) have significant pathogenic potential will not be as infrequent as might be expected under the CDRV hypothesis.

Finally, the effect of MALT1-API2 expression on API2-MALT1-mediated NF-κB activation was examined by co-expression of the different API2-MALT1 fusion variants A7M3/A7M5/A7M8 in combination with their corresponding WT or RM MALT1-API2 variant M2A8/M4A8/M7A8 in HEK-293T.