Sentence examples for variants in cells from inspiring English sources

Studies involving pharmacological chaperones have shown some effect on retained V2 receptor variants in cells [ 29] and displayed beneficial effects in patients [ 30] whereas treatments targeting phosphorylation and trafficking defective AQP2, like AQP2-R254W, remain to be explored.

We then assessed the presence of variants in cells depleted to 50%, 20 % and 3 of their original mtDNA content and then allowed to recover in culture over 14 days.

Of note in this context is that the individual activation of TRAIL-R1 and -R2 could be an advantage, since it was shown that combined exposure to DR4- and DR5-selective TRAIL variants in cells, sensitive for both receptors, was more potent in triggering apoptosis when compared to single agent treatment [ 22].

To describe the behavior of the system, we formulate differential equations in the standard way by ignoring variants in cell density (caused by cell growth and division, for example).

Further analysis using primers specific to the common exons (exon 2 and 3) of OPCML variants in cell lines without both v1 and v2 transcripts revealed the presence of even more unidentified, alternative promoter usage (Fig. 1F).

This is indeed one of the phenotypes of some of our Twinkle variants in cell culture.

The function of the variants in cell proliferation is not known.

We observed a much larger number of both open chromatin sites and overlaps of these sites with trait-associated variants in cell lines compared to primary cells.

Ultimately, the direct modelling of these variants in cell lines and model organisms may be required for final confirmation of causality.

Our results show that the combined risks of variants in cell death pathway genes are associated with the cervical cancer as well as the HSV-2 infection in the black African and mixed-ancestry population.

We describe here, using various knockout transfer DNA (T-DNA) insertion mutants and RNA interference (RNAi) knockdown plants in multiple combinations, the roles of the three Arabidopsis vegetative protein variants in cell, tissue, and organ development.