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Fig. 2 Strategy for finding variants in cases with family segregation.
The values reported in this study correspond to the moment or root movement variants in cases of play minimization by the use of terminal sized or excessively torqued archwires, which should counteract the play and care should be exercised in transferring the results of this investigation to the clinical situation.
Our third question arises when sequencing is used to both discover and count variants in cases and controls, and we wish to focus our comparison on rare alleles.
To investigate whether individuals with combinations of TIRAP SNPs might influence disease occurrence, we undertook analysis of the frequency of combinations of two or more variants in cases and controls.
From these two sets of studies we performed two types of analyses: 1) From the first set of studies we extracted from each the difference in levels (or biological activity) of the IP between the two homozygous variants, or between the wild-type and heterozygous variants in cases of dominant polymorphisms.
In light of data showing viral genetic homogeneity in most individuals with acute/early HIV-1 infection [17] [23] it was decided that deeper sequencing on the HIV-1 infected partner would be performed to identify potentially low-level transmitted variants in cases of initially unlinked or indeterminate pairs eligible for inclusion as trial endpoints.
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The minor allele frequency of the Pro72Arg tp53 gene variant in cases and controls was 24.9% versus 26.6% (P = 0.57).
However, we observed that none of these publications demonstrated variant-specific statistically significant enrichment for this variant in cases versus controls.
The allele frequency of the variant in "cases" with end-stage renal disease was 0.0297 and 0.039 in the control type 1 diabetics without nephropathy.
Familiarity with these signs can prevent misinterpretation of the ALPSA lesion as an anatomic variant in cases with only slight displacement of the labrum.
We first consider expanding the list of known variants by concentrating variant-discovery in cases.
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