Sentence examples for variants impact the from inspiring English sources

An implicit goal of ENIGMA is to see whether genetic variants impact the brain in a way that affects disease risk.

Leandro et al. interrogated IFNG+874*T/A and NOS2A-954*G/C NOS2A-954*G/Ce-control (n = 172/ n = 179) SNPsy to estinate their role on susceptibility to tuberculosis and to determine whether those variants impact the levels of nitrite and nitric oxide radical in serum.

In light of these data, it is thus not surprising that genetic variants impacting the function of genes within these systems have been shown to moderate the effects of early trauma on depression.

In accordance with recent findings, this may suggest that RGS4 variants impact on the functional integrity of the prefrontal cortex, thus increasing susceptibility for psychotic spectrum disorders.

Those results point to a cis-acting variant impacting the expression of PARK2 in the liver of divergent chicken lines, emphasizing the potential causal status of this gene for adiposity.

Nonetheless, reporter assays demonstrated that the TSS variants impacted on the translational readout both quantitatively (the overall amount of protein expressed) and qualitatively (the nature of the proteins expressed).

Further study should focus on how these genetic variants impact function at the molecular and cellular levels to affect NPC development.

To strengthen the conclusion that ASD variants impact genes involved in the nucleotide metabolism pathway, we performed experimental qPCR validation on this set of CNVs and found all were valid except one deletion arising due to cell line artifact in the FHIT gene.

Finally, the SnpEff annotations also provide an estimate of the variant impact on the protein function [ 25].

It may indicate that more samples are needed to determine its functional effect or the genetic variants impact on disease susceptibility by other mechanisms instead of cis-eQTL effect.

If a truncating variant is confined to only one or not all transcripts, one must be cautious about over-interpreting variant impact given the presence of the other protein isoforms.