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Yet, classical multistage switching architectures with their Space-Memory variants have shown limited performance.
To our best knowledge, the only previous study in addressing the application of BFP, a Y66H type of GFP variants have shown limited utility in monitoring viral movement in plants because its brightness was significantly influenced by the cellular pH environments among plant species (Diveki et al. [2002]).
Thus, while a small number of common variants have shown evidence for genetic association with bipolar disorder and/or schizophrenia, the vast majority of the heritability for these disorders remains unexplained by GWAS studies to date.
Indeed certain GAS6 variants have shown considerable differences between populations from Europe and Asia [ 23, 24, 34, 35].
Studies of CNVs and other rare alleles have found overlap between autism and schizophrenia, whereas those of common SNP variants have shown overlap between schizophrenia and bipolar disorder.
Nevertheless, subsequent studies with CALB variants have shown that the contributions of these invisible regions can be more complex and critical to function.
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An attempt to compose a GRS combining several genetic variants has shown only a 10 12% increased risk of disease with increasing number of the risk alleles.
However, recent experience with drug-resistant variants has shown that the majority of these variants are deficient in the expression of thymidine kinase [ 7- 9], a phenotype that is known to be associated with a reduced ability to reactivate [ 8- 10].
The comparison of stable NIH 3T3 cell lines expressing FGFR3 WT, FGFR3 V555M or FGFR3 K650E variants has shown that the phosphorylation of FGFR3 V555M is increased compared to the WT but is not as high as observed for the activated form FGFR3 K650E (Fig. 4C).
Further assessment of the effects of enhancer risk variants has shown that they can alter transcription-factor-binding sites (TFBSs) and impact the affinity of transcription factors for chromatin, and/or induce allele-specific effects on target gene expression [ 6, 27- 40].
The study of LA dynamics in the tissues of above ground parts of seedlings from the control variant have shown gradual increase of LA index to the fifth day with subsequent decrease to the initial levels on the seventh day (Fig. 2).
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