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It originated in 1999 in the US, on a libertarian website called Capitol Hill Blue - the giveaway is the "little over 500", the size of the US House and Senate combined - and similar variants have previously been found in Canada and India.
These variants have previously been reported to be associated with ASD and key components of ASD [16] [19].
Myostatin gene (MSTN) variants have previously been shown to contribute to muscle hypertrophy in a range of mammalian species [1], [2], [3], [4], [5].
The 3H and 3S epitope variants have previously been identified as weak agonists of CTL clone 003 27, 27.
The PPARG gene locus and gene variants have previously been addressed in a Human Genome Epidemiology (HuGE) review on the genetics of leptin and obesity (6).
Out of the eight genetic variants classified as polymorphisms, frequency data on seven of the variants have previously been published [ 23].
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Eighty-six P/LP variants had previously been detected either by standard molecular pathology and cytogenetics (n = 55) or exclusively as part of the PCGP (n = 31) (Supplementary Data 7A).
Unlike MMP1 and MMP3, none of these variants has previously been associated with RCC risk in sporadic patients [13].
For the remaining 4 genes which have only infrequently been identified as causal for LCA, only exons in which variants had previously been identified were sequenced.
The ability of common tSNPs/haplotypes to capture rare functional variants has previously been demonstrated for the angiotensinogen (AGT) gene [42].
To test for shared effects down-stream of DISC1, the same global analysis was performed on other members of the DISC1 pathway for which variants had previously been reported as associated with schizophrenia or related psychotic traits in European cohorts.
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CEO of Professional Science Editing for Scientists @ prosciediting.com