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If TE insertion variants have contributed to adaptive gene evolution, such variants might be expected to be in high frequency or fixed in populations and species.
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There is little evidence that these culturally transmitted variants would have contributed significantly to the differential fitness of their bearers.
Moreover, changes in oligosaccharide structures of HP variants may have contributed to tumorigenesis [ 34– 34].
Revertant cells, which can be isolated from transformed cells, are flat, non-transformed variants that have contributed to the elucidation of mechanisms involved in cell transformation.
Selective pressure to maintain some of the sequence variants could have contributed to the retention of some SNPs in both M. fascicularis and M. mulatta.
The high mouse virulence of all strains tested suggests that signature nucleotide and amino acid changes associated with the different genotypes involved (4, 10 ) were probably not linked to major changes in virulence for mammalian hosts, and that all 3 variants might have contributed to human disease in the 2010 outbreak.
Most in the field have come to appreciate that both the common and rare variant hypotheses have contributed significantly to our understanding of human disease susceptibility (Schork et al. 2009).
Our 384-plex SNP panel included a mix of novel (not previously validated) and common variants which could have contributed to the observed slightly lower call rates.
Our analysis has led to the identification of genetic features of the original devil that gave rise to DFTD, a description of the underlying mutational processes that have characterized DFTD progression, annotation of gene variants that may have contributed to DFTD pathogenesis, and a map of the clonal dynamics of the disease during its spread through Tasmania.
It is highly possible that the sequence deletions, insertion, and mutations found in variant strain OH851 might have contributed to the reduced severity of the clinical disease in the piglets.
Aladro-Gonzalvo et al. (2012) [ 10] also conducted a meta-regression analysis to identify co-variants that may have contributed to the heterogeneity of treatment effect across studies [ 23].
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