Sentence examples for variants has led from inspiring English sources

Subretinal administration of many of these AAV variants has led to efficient gene expression in a number of retinal neurons and epithelia, including photoreceptors and RPE [14], [15], and it is thus the injection route employed by current clinical therapies to achieve sufficient transduction for rescue [2].

The search for these genetic variants has led to genome-wide association studies (GWAS), which have so far reported 49 single nucleotide polymorphisms (SNPs) associated with PrCa risk [ 8– 24].

The current wealth of genome-wide association studies revealing statistical associations between disease traits and common genetic variants has led to keen interest in trying to assign specific functional consequences to each such variant.

Thus it may be deduced that the amino acid changes already observed in the ON1 variants have led to profound differences in its antigenic profile.

Advances in genomic technologies that facilitate genome-wide discovery of both common and rare variants have led to a rapid increase in our understanding of epilepsy genetics.

These considerations, along with the high heritability of TL and recent discovery of TL-related genetic variants, have led to an interest in studies where the relationship between genetic predictors of TL and disease risk is investigated.

Failure to detect the plasmid and hence treat those infected with the new variant has led to a significant increase in cases, and in some Swedish counties 20 – 64% of current infections are caused by this strain of C. trachomatis [ 10].

The finding of significantly different PrPres profiles for sporadic CJD and variant CJD has led to speculation of an analogous spontaneous rare sporadic form of BSE in cattle that might even have been the origin of the BSE epidemic [ 37, 41, 47].

For example, the availability of large population variant frequency data has led many "uncertain significance" variants to be re-classified as benign, and testing additional family members may result in the re-classification of variants.

Identification of genetic mutations in APP associated with familial forms of AD and gene polymorphisms associated with the more common sporadic variants of AD has led to the development of transgenic (tg) and knock out rodents as well as viral vector driven models of AD.

Knowledge of the association of specific variants with animal hosts has led to increasingly effective control measures that target the hosts responsible for spreading this disease (11 ).